β-cell dedifferentiation in diabetes is important, but what is it?

β-cell dedifferentiation in diabetes is important, but what is it?

This commentary discusses the concept of β-cell dedifferentiation in diabetes, which is important but not well defined. A broad interpretation is that a state of differentiation has been lost, which means changes in gene expression as well as in structural and functional elements. Thus, a fully mature healthy β cell will have its unique differentiation characteristics, but maturing cells and ol...

What is heterogeneity and is it important?

health communication what it is and what is not

Rheumatoid cachexia: what is it and why is it important?

Radiogenomics: what it is and why it is important.

In recent years, a new direction in cancer research has emerged that focuses on the relationship between imaging phenotypes and genomics. This direction is referred to as radiogenomics or imaging genomics. The question that subsequently arises is: What is the practical significance of elucidating this relationship in improving cancer patient outcomes. In this article, I address this question. A...